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Spinal Cord Injury and Traumatic Brain Injury Research Grant Program


 

The Office of Higher Education administers the Spinal Cord Injury and Traumatic Brain Injury Research Grant Program for research into new and innovative treatments and rehabilitative efforts for the functional improvement of people with spinal cord and traumatic brain injuries. Research topics may include, but are not limited to, pharmaceutical, medical device, brain stimulus, and rehabilitative approaches and techniques.

Funding Sources

The State of Minnesota established the Spinal Cord Injury and Traumatic Brain Injury Grant Program effective July 1, 2015 with a $500,000 per year appropriation. Research funding from the Legislature is split 50/50 between spinal cord injuries and traumatic brain injuries. In 2017, the legislature added an additional $5 million for the biennium to support spinal cord and traumatic brain injury research, for a total of $6,000,000 for the biennium split between the two research areas. These grant awards were also supplemented by a $15,000 program donation from the Get Up to Cure Paralysis Foundation.

Fiscal Year 2021 Request for Proposals

POSTPONED UNTIL FURTNER NOTICE

In consultation with the Spinal Cord Injury and Traumatic Brain Injury Advisory Council, the Minnesota Office of Higher Education is currently accepting proposals for the Spinal Cord Injury and Traumatic Brain Injury Annual Research Grant. In fiscal year 2020, there is $1,455,000 available to fund initiatives focusing on spinal cord injury research, and $1,455,000 available to fund initiatives focusing on traumatic brain injury research. The overall objective of this program is to foster and encourage innovative research for treatment and rehabilitative techniques for spinal cord and traumatic brain injuries.

Three funding options are available:

Tier 1: Pilot Project Grant

  • Max Request: $125,000.
  • Project Time: 2 years + 1-year no cost extension.
  • Project Details: Reflects early investment as the researcher prepares to seek a larger grant award from a federal program or nonprofit organization. Preliminary data is not required.

Tier 2: Standard Research Grant

  • Max Request: $250,000.
  • Project Time: 2 years + 1-year no cost extension.
  • Project Details: Primarily for research with supporting/preliminary data. If the budget is justifiable, the Standard Research Grant may also fund pilot projects. Applicants are encouraged to attach papers; in-press and accepted papers and cited or submitted separately as an appendix.

Tier 3: Clinical/Translational Research Grant

  • Max request: $500,000.
  • Project Time: 3 years + 2 year no-cost extension.
  • Project Details: Projects must have concurrent application or funding from federal or industry sources. Preliminary data must be published or in press in a scientific journal and cited or submitted separately as an appendix.
Intent to Submit forms are due on February 28 2020. Proposals are due by 4:30pm on April 3, 2020.

For more information, see our Request for Proposals.

Grant Recipients 2020

In May 2019, the Spinal Cord and Traumatic Brain Injury Advisory Council convened to review proposals for fiscal year 2020. As a result, sixteen projects were funded. The 2020 Spinal Cord and Traumatic Brain Injury grantees are:

Spinal Cord Injury Research

  • Hennepin Healthcare/University of Minnesota: ESTAND 2.0 -Bridge to Clinical Approval of eSCS for SCI
  • University of Minnesota: Spinal Cord Regeneration by Cell Reprogramming in Chronic Spinal Cord Injury
  • Hennepin Healthcare: Non-invasive Transcutaneous Spinal Cord Stimulation for Recovery of Hand Function after Spinal Cord Injury
  • University of Minnesota: 3D Bioprinted spinal Neuro Progenitor Cell (sNPC) Scaffolds Accelerate Functional Neuronal Network Formation in both in vitro and in vivo after Spinal Cord Injury
  • Mayo Clinic: 3D Bioprinted spinal Neuro Progenitor Cell (sNPC) Scaffolds Accelerate Functional Neuronal Network Formation in both in vitro and in vivo after Spinal Cord Injury
  • Mayo Clinic: Therapeutic Targeting of Cellular Senescence to Promote Repair of the Chronically Injured Spinal Cord
  • University of Minnesota: Optimization of iPSC-derived Oligodendrocyte Progenitor Cell (OPC) Manufacture- a Key Step Toward Patient Treatment

Traumatic Brain Injury Research

  • Mayo Clinic: Identification of Brainwide Network Activity Changes in Post-traumatic Epilepsy to Optimize the Therapeutic Effect of Vagus Nerve Stimulation on Post-traumatic Epilepsy
  • Mayo Clinic: Switching Off the Thrombin Receptor to Enhance Recovery after Traumatic Brain Injury
  • University of Minnesota: Multilineage 3-Dimensional Brain Organoids to Model Intracranial Pressure Linked to Chronic Traumatic Encephalopathy
  • University of Minnesota: Characterizing the Neuroinflammation Associated with Sequential TBI in a Rodent Model
  • ExcercisAbilities; Winona State University: Validation of Cardiovascular Exercise Tests for Individuals with Traumatic Brain Injury
  • HealthPartners Institute: Acupuncture Treatment for Chronic Post-traumatic Headache in Individuals with Mild Traumatic Brain Injury
  • Center for Veterans Research and Education/Minneapolis VA Health: Improving Communication about Sexual Health for Persons Undergoing Acute Inpatient Rehabilitation for Traumatic Brain Injury (TBI)
  • CentraCare Health -St. Cloud Hospital: Improving Functional Outcomes through Optimization of Surgical Subdural Hematoma Evacuation Technique
  • Center for Veterans Research and Education/Minneapolis VA Health: Theta Burst Stimulation for Headaches after Traumatic Brain Injury

Grant Recipients 2019

In May 2018, the Spinal Cord and Traumatic Brain Injury Advisory Council convened to review proposals for fiscal year 2019. As a result, nineteen projects were funded. The 2019 Spinal Cord and Traumatic Brain Injury grantees are:

Spinal Cord Injury Research

  • Mayo Clinic: Spinal Cord Tissue Regeneration through Schwann Cell Seeded Hydrogel Scaffolds with Spatial-Selective Electrical Stimulation
  • Mayo Clinic: Direct Comparison of Transcutaneous and Epidural Spinal Stimulation to Enable Motor Function in Humans with Motor Complete Paraplegia
  • Mayo Clinic: New Combinational Strategies for Regenerative Repair of the Injured Spinal Cord
  • HealthPartners Institute: Intranasal Insulin to Improve Recovery following Cervical Spinal Cord Injury
  • Hennepin Healthcare-HCMC/Minneapolis Medical Research Foundation, Minneapolis VA: iRehab: Discovering Outpatient Rehabilitative Measures for Epidural Stimulation Assisted Movement
  • Hennepin Healthcare-HCMC/Minneapolis Medical Research Foundation, University of Minnesota: iOptimize: Optimization of Epidural Stimulation for Spinal Cord Injury
  • Regents of the University of Minnesota: Targeting Estrogen Receptors to Restore Spinal Plasticity in Acute Spinal Cord Injury
  • Regents of the University of Minnesota: Training Transplanted Spinal Neuronal Progenitor Cells to Function after Chronic Spinal Cord Injury
  • Regents of the University of Minnesota: Optogenetics for Corticospinal Tract Stimulation in Combination with Transplanted Spinal Neuronal Progenitor Cells after Spinal Cord Injury

Traumatic Brain Injury Research

  • Minneapolis Medical Research Foundation & HCMC: Neuroimaging and Neurovision Rehabilitation for Neurocognitive Deficits secondary to Oculomotor Dysfunction in Mild Traumatic Brain Injury
  • Minneapolis Medical Research Foundation & HCMC: Correlation between Eyetracking and Developmental Optometry in Oculomotor Dysfunction following Traumatic Brain Injury
  • Minneapolis Medical Research Foundation, HCMC & University of Minnesota: Cortical Spreading Depolarization after Severe Traumatic Brain Injury
  • Minneapolis VA Healthcare System: Combined tDCS and Cognitive Training to Reduce Impulsivity in Patients with Traumatic Brain Injury
  • Minneapolis VA Healthcare System: Head-mounted Display Virtual Reality in the Treatment of Upper Extremity Function in Acute TBI Rehabilitation: A Comparison Study to Conventional OT Treatment
  • Regents of the University of Minnesota: Evolution of Acute and Chronic Effects on Neuronal Activity and Morphology following Mild Cerebral Cortical Traumatic Brain Injury using Multi-Scale Optical Imaging in Behaving Mice
  • Regents of the University of Minnesota: The Roles of Tau in Chronic Traumatic Encephalopathy
  • Regents of the University of Minnesota: Harnessing Exosomes as a Biomarker and Therapeutic Approach to Traumatic Brain Injury
  • Regents of the University of Minnesota: Reprogramming Astrocytes into Neurons to Provide Therapeutic Benefit to TBI
  • Minneapolis Medical Research Foundation: Acute Biomarkers for Traumatic Brain Injury Across the Severity Scale

Reports

Download reports to the Minnesota Legislature on the institutions receiving grants and their purpose.